Keywords: Cyanides, antidotes, poisoning, amyl nitrite, cobinamide, edetic acid (dicobalt edetate), 4-dimethylaminophenol, Research for new, safer and more effective cyanide antidotes continues. For example, hydroxocobalamin is safer than the methemoglobin inducers in patients with Each antidote hasĪdvantages and disadvantages. Induction, and sulfane sulfur supplementation for detoxification by endogenous rhodanese. Antidotal mechanisms include chelation, formation of stable, less toxic complexes, methemoglobin All currently marketed antidotesĪppear to be effective. ![]() Multiple antidotes exist and vary in regional availability. Our present knowledge supports cyanide poisoning treatment based on excellent supportive care The onset and severity of poisoning depend on the route, dose, physicochemical structure and other variables.Ĭommon poisoning features include dyspnea, altered respiratory patterns, abnormal vital signs, altered mental status, seizures,Īnd lactic acidosis. The primary target of toxicity is mitochondrial cytochrome ![]() Products, multiple physical forms, and chemical structures. Cyanide poisoning can present in multiple ways, given its widespread industrial use, presence in combustion
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